Rebooting Regulatory T Cell and Dendritic Cell Function in Immune-Mediated Inflammatory Diseases: Biomarker and Therapy Discovery under a Multi-Omics Lens

Dimitra Kerdidani, Nikos E. Papaioannou, Evangelia Nakou and Themis Alissafi

Biomedicines 2022, 10(9), 2140;



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Regulatory T Cells in Autoimmunity and Cancer: A Duplicitous Lifestyle
Aikaterini Hatziioannou, Athina Boumpas, Miranta Papadopoulou, Iosif Papafragkos, Athina Varveri, Themis Alissafi and Panayotis Verginis
Front Immunol 2021 Sep 3;12:731947.
doi: 10.3389/fimmu.2021.731947.


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Patrolling human SLE haematopoietic progenitors demonstrate enhanced extramedullary colonisation; implications for peripheral tissue injury
Ioannis Kokkinopoulos, Aggelos Banos, Maria Grigoriou, Anastasia Filia, Theodora Manolakou, Themis Alissafi, Nikolaos Malissovas, Ioannis Mitroulis, Panayotis Verginis, Dimitrios T Boumpas
Sci Rep 2021 Aug 3;11(1):15759.
doi: 10.1038/s41598-021-95224-y.


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Regulatory T-cell Transcriptomic Reprogramming Characterizes Adverse Events by Checkpoint Inhibitors in Solid Tumors
Maria Grigoriou, Aggelos Banos, Aikaterini Hatzioannou, Andreas Kloetgen, Panagiotis Kouzis, Despoina Aggouridaki, Roubini Zakopoulou, Giorgos Bamias, Eva Kassi, Dimitrios Mavroudis, Aristotelis Bamias, Dimitrios T Boumpas, Aristotelis Tsirigos, Helen Gogas, Themis Alissafi, Panayotis Verginis
Cancer Immunol Res 2021 Jul;9(7):726-734.
doi: 10.1158/2326-6066.CIR-20-0969.

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Measuring Suppressive Activity and Autophagy in Myeloid-Derived Suppressor Cells
Antonis Stylianos Papaioannou, Athina Boumpas, Miranta Papadopoulou, Aikaterini Hatzioannou, Themis Alissafi, Panayotis Verginis
Methods Mol Biol 2021;2236:85-98.
doi: 10.1007/978-1-0716-1060-2_9.

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Mitochodrial Oxidative Damage Underlies Regulatory T cells Defects in Autoimmunity
Alissafi T, Kalafati L, Lazari M, Filia A, Kloukina I, Manifava M, Lim JH, Alexaki VI, Ktistakis NT, Doskas T, Garinis GA, Chavakis T, Boumpas DT, Verginis P
Cell Metab. 2020 Oct 6;32(4):591-604.e7.
doi: 10.1016/j.cmet.2020.07.001.


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Balancing cancer immunotherapy and immune related adverse events:The emerging role of regulatory T cells
T Alissafi, A Hatziioannou, A.I. Legaki, A Varveri, Panayotis Verginis
J Autoimmun 2019 Nov;104:102310.
 doi: 10.1016/j.jaut.2019.102310.

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Autophagy orchestrates the regulatory program of tumor-associated myeloid-derived suppressor cells
Alissafi T, Hatzioannou A, Mintzas K, Barouni RM, Banos A, Sormendi S, Polyzos A, Xilouri M, Wielockx B, Gogas H, Verginis P
J Clin Invest. 2018 Aug 31; 128(9):3840-3852.
doi: 10.1172/JCI120888.


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